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Dr. Michelle E. Melisko is a cancer specialist with expertise in breast cancer treatment and research. She is interested in testing new chemotherapy combinations, biological therapies and immunotherapies for breast cancer, with a particular focus on treatment of cancer that has spread to the brain. She also hopes to educate patients and encourage their participation in clinical trials to make more rapid advances in breast cancer treatment.
Melisko earned a medical degree at the Wake Forest University School of Medicine and completed a residency in internal medicine at Stanford Hospital and Clinics and a fellowship in hematology and oncology at UCSF Medical Center.
Publications
System-Level Transformations to Increase Patient Participation in Clinical Trials.
JCO oncology practice
Implementation and impact of an electronic patient reported outcomes system in a phase II multi-site adaptive platform clinical trial for early-stage breast cancer.
Journal of the American Medical Informatics Association : JAMIA
NCCN Guidelines® Insights: Survivorship, Version 2.2024.
Journal of the National Comprehensive Cancer Network : JNCCN
Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways.
Journal of neural transmission (Vienna, Austria : 1996)
Regional lymph node changes on breast MRI in patients with early-stage breast cancer receiving neoadjuvant chemo-immunotherapy.
Breast cancer research and treatment
Neratinib and Ado-Trastuzumab-Emtansine for Pre-treated and Untreated HER2-positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium Trial 022.
Annals of oncology : official journal of the European Society for Medical Oncology
Demographic and clinical characteristics of patients with metastatic breast cancer and leptomeningeal disease: a single center retrospective cohort study.
Breast cancer research and treatment
68Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18F-FDG.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Changing the Perspective on Fertility Preservation for Women with Metastatic or Advanced Stage Cancer.
Current oncology reports
TBCRC 057: Survey about willingness to participate in cancer clinical trials during the pandemic.
Cancer medicine
Neoadjuvant trebananib plus paclitaxel-based chemotherapy for stage II/III breast cancer in the adaptively randomized I-SPY2 trial - Efficacy and biomarker discovery.
Clinical cancer research : an official journal of the American Association for Cancer Research
Management of Concurrent Malignant Phyllodes Tumor and Invasive Breast Carcinoma.
Advances in radiation oncology
Targeting HER2-mutant metastatic cervical cancer with neratinib: Final results from the phase 2 SUMMIT basket trial.
Gynecologic oncology
Characterizing attitudes related to future child-bearing in young women diagnosed with early-stage breast cancer.
Breast cancer research and treatment
Left atrial strain is reduced following trastuzumab in breast cancer patients.
Echocardiography (Mount Kisco, N.Y.)
Concordance between patient-reported and physician-documented comorbidities and symptoms among Stage 4 breast cancer patients.
Cancer medicine
Survivorship wellness: a multidisciplinary group program for cancer survivors.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Tamoxifen or aromatase inhibitors with ovarian function suppression in pre-menopausal stage I-III lobular breast cancer.
NPJ breast cancer
A phase Ib/II study of eribulin in combination with cyclophosphamide in patients with advanced breast cancer.
Breast cancer research and treatment
NCCN Guidelines® Insights: Survivorship, Version 1.2023.
Journal of the National Comprehensive Cancer Network : JNCCN
Crofelemer for the Management of Neratinib-Associated Diarrhea in Patients With HER2+ Early-Stage Breast Cancer.
Clinical breast cancer
High-dimensional immune cell profiling of cerebrospinal fluid from patients with metastatic breast cancer and leptomeningeal disease.
NPJ breast cancer
Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer.
NPJ breast cancer
Clinical characteristics and outcomes in patients with metastatic breast cancer and pseudocirrhosis: a single center retrospective cohort study.
Breast cancer research and treatment
ASO Visual Abstract: The 21-Gene Recurrence Score in Clinically High Risk Lobular and Ductal Breast Cancer-A National Cancer Database Study.
Annals of surgical oncology
GLORIA: phase III, open-label study of adagloxad simolenin/OBI-821 in patients with high-risk triple-negative breast cancer.
Future oncology (London, England)
A Pilot Study of Associations Between the Occurrence of Palpitations and Cytokine Gene Variations in Women Prior to Breast Cancer Surgery.
Biological research for nursing
NCCN Guidelines� Insights: Survivorship, Version 1.2022.
Journal of the National Comprehensive Cancer Network : JNCCN
Polymorphisms in Cytokine Receptor and Regulator Genes are Associated with Levels of Exercise in Women Prior to Breast Cancer Surgery.
Biological research for nursing
The 21-Gene Recurrence Score in Clinically High-Risk Lobular and Ductal Breast Cancer: A National Cancer Database Study.
Annals of surgical oncology
The incidence of discordant clinical and genomic risk in patients with invasive lobular or ductal carcinoma of the breast: a National Cancer Database Study.
NPJ breast cancer
A case-case analysis of women with breast cancer: predictors of interval vs screen-detected cancer.
Breast cancer research and treatment
Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial.
Nature communications
Decreased enrollment in breast cancer trials by histologic subtype: does invasive lobular carcinoma resist RECIST?
NPJ breast cancer
Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer.
NPJ breast cancer
Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.
NPJ breast cancer
Authors' Reply: To the Letter to the Editor by Groheux et al.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship, Version 1.2021.
Journal of the National Comprehensive Cancer Network : JNCCN
Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer ("METRIC"): a randomized multicenter study.
NPJ breast cancer
Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II-III Breast Cancer: A Multicenter Value Analysis.
Journal of the National Comprehensive Cancer Network : JNCCN
TBCRC 048: Phase II Study of Olaparib for Metastatic Breast Cancer and Mutations in Homologous Recombination-Related Genes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
The quality of life index: a pilot study integrating treatment efficacy and quality of life in oncology.
NPJ breast cancer
Psychological Symptoms and Stress Are Associated With Decrements in Attentional Function in Cancer Patients Undergoing Chemotherapy.
Cancer nursing
NCCN Guidelines Insights: Survivorship, Version 2.2020.
Journal of the National Comprehensive Cancer Network : JNCCN
Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer.
Nature communications
Assessing preferences for receiving supportive care resources among patients seen at a Breast Care Center.
Breast cancer research and treatment
Treatment of Metastatic Melanoma With Leptomeningeal Disease Using Intrathecal Immunotherapy.
JCO oncology practice
Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer.
Journal of neuro-oncology
Alterations in Patterns of Gene Expression and Perturbed Pathways in the Gut-Brain Axis Are Associated With Chemotherapy-Induced Nausea.
Journal of pain and symptom management
Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022.
Clinical breast cancer
Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.
Journal of neuroimmunology
NCCN Guidelines Insights: Survivorship, Version 2.2019.
Journal of the National Comprehensive Cancer Network : JNCCN
Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease.
Breast cancer research and treatment
Fitbit Usage in Patients With Breast Cancer Undergoing Chemotherapy.
Clinical breast cancer
Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial.
Clinical cancer research : an official journal of the American Association for Cancer Research
TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Integration of Health Questionnaire Systems to Facilitate Supportive Care Services for Patients at an Academic Breast Care Center.
JCO clinical cancer informatics
Survivorship, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JNCCN
The DigniCap Scalp Cooling System and its use in the treatment of chemotherapy-induced alopecia.
Future oncology (London, England)
Menopausal-Related Symptoms in Women One Year After Breast Cancer Surgery.
Journal of pain and symptom management
The value of embedding: integrated palliative care for patients with metastatic breast cancer.
Breast cancer research and treatment
Registry study to assess hair loss prevention with the Penguin Cold Cap in breast cancer patients receiving chemotherapy.
Breast cancer research and treatment
Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JNCCN
Evaluation of coping as a mediator of the relationship between stressful life events and cancer-related distress.
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
Concerns About Methodology of a Trial Investigating Vaginal Health During Aromatase Inhibitor Therapy for Breast Cancer-Reply.
JAMA oncology
Erratum to: Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy.
Breast cancer research and treatment
Fertility preservation with ovarian stimulation and time to treatment in women with stage II-III breast cancer receiving neoadjuvant therapy.
Breast cancer research and treatment
Modifiable and non-modifiable characteristics associated with sleep disturbance in oncology outpatients during chemotherapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer.
JAMA
A randomized pilot trial of a positive affect skill intervention (lessons in linking affect and coping) for women with metastatic breast cancer.
Psycho-oncology
Adaptive Randomization of Neratinib in Early Breast Cancer.
The New England journal of medicine
NCCN Guidelines Insights: Survivorship, Version 1.2016.
Journal of the National Comprehensive Cancer Network : JNCCN
Quality of Posttreatment Care Among Breast Cancer Survivors in the University of California Athena Breast Health Network (Athena).
Clinical breast cancer
Sexual Function in Cancer Survivors: Updates to the NCCN Guidelines for Survivorship.
Journal of the National Comprehensive Cancer Network : JNCCN
Gene Expression Profiling of Evening Fatigue in Women Undergoing Chemotherapy for Breast Cancer.
Biological research for nursing
A phase 1b study of the Akt-inhibitor MK-2206 in combination with weekly paclitaxel and trastuzumab in patients with advanced HER2-amplified solid tumor malignancies.
Breast cancer research and treatment
Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
The symptom phenotype of oncology outpatients remains relatively stable from prior to through 1 week following chemotherapy.
European journal of cancer care
Issues in Breast Cancer Survivorship: Optimal Care, Bone Health, and Lifestyle Modifications.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Detection of cerebrospinal fluid tumor cells and its clinical relevance in leptomeningeal metastasis of breast cancer.
Breast cancer research and treatment
Association of tamoxifen use and ovarian function in patients with invasive or pre-invasive breast cancer.
Breast cancer research and treatment
Comparison of subgroups of breast cancer patients on pain and co-occurring symptoms following chemotherapy.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Predictors and Trajectories of Morning Fatigue Are Distinct From Evening Fatigue.
Journal of pain and symptom management
Trajectories of Evening Fatigue in Oncology Outpatients Receiving Chemotherapy.
Journal of pain and symptom management
The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Survivorship: screening for cancer and treatment effects, version 2.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: nutrition and weight management, Version 2.2014. Clinical practice guidelines in oncology.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: healthy lifestyles, version 2.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: immunizations and prevention of infections, version 2.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases.
Breast cancer research and treatment
Survivorship: cognitive function, version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: fatigue, version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: sleep disorders, version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Genome-wide copy number analysis of cerebrospinal fluid tumor cells and their corresponding archival primary tumors.
Genomics data
Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Survivorship: pain version 1.2014.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: sexual dysfunction (male), version 1.2013.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: sexual dysfunction (female), version 1.2013.
Journal of the National Comprehensive Cancer Network : JNCCN
Survivorship: introduction and definition. Clinical practice guidelines in oncology.
Journal of the National Comprehensive Cancer Network : JNCCN
A randomized, phase II, three-arm study of two schedules of ixabepilone or paclitaxel plus bevacizumab as first-line therapy for metastatic breast cancer.
Breast cancer research and treatment
Provider perceptions and expectations of breast cancer posttreatment care: a University of California Athena Breast Health Network project.
Journal of cancer survivorship : research and practice
Survivorship clinic group educational sessions: adoption, acceptance, and attendance.
Journal of cancer education : the official journal of the American Association for Cancer Education
Clinical trial discussion, referral, and recruitment: physician, patient, and system factors.
Cancer causes & control : CCC
Differences in sleep disturbance, fatigue and energy levels between women with and without breast pain prior to breast cancer surgery.
Breast (Edinburgh, Scotland)
The impact of an electronic health questionnaire on symptom management and behavior reporting for breast cancer survivors.
Breast cancer research and treatment
Patient perceptions of reproductive health counseling at the time of cancer diagnosis: a qualitative study of female California cancer survivors.
Journal of cancer survivorship : research and practice
Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment.
Genome medicine
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer.
British journal of cancer
A feasibility study of bevacizumab plus dose-dense doxorubicin-cyclophosphamide (AC) followed by nanoparticle albumin-bound paclitaxel in early-stage breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Long-term prognostic role of functional limitations among women with breast cancer.
Journal of the National Cancer Institute
A changing perspective: improving access to fertility preservation.
Nature reviews. Clinical oncology
Amelioration of sexual adverse effects in the early breast cancer patient.
Journal of cancer survivorship : research and practice
A phase I trial of immunotherapy with lapuleucel-T (APC8024) in patients with refractory metastatic tumors that express HER-2/neu.
Clinical cancer research : an official journal of the American Association for Cancer Research
New challenges and opportunities in the management of brain metastases in patients with ErbB2-positive metastatic breast cancer.
Nature clinical practice. Oncology
Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival.
Journal of neuro-oncology
Treatment with autologous antigen-presenting cells activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer.
Breast cancer research and treatment
Brain metastases of breast cancer.
Expert review of anticancer therapy
Case report: painful peripheral neuropathy following treatment with docetaxel for breast cancer.
Clinical journal of oncology nursing
Patient and physician attitudes toward breast cancer clinical trials: developing interventions based on understanding barriers.
Clinical breast cancer
Reactivation of hepatitis C virus after chemotherapy for colon cancer.
Clinical oncology (Royal College of Radiologists (Great Britain))