
Associate Professor
M_Oto-General OHNS
The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.
Publications
IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma.
bioRxiv : the preprint server for biology
Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade.
Journal for immunotherapy of cancer
Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.
bioRxiv : the preprint server for biology
T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation.
Cancer immunology research
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states.
bioRxiv : the preprint server for biology
A mass cytometry method pairing T cell receptor and differentiation state analysis.
Nature immunology
A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy.
ArXiv
Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.
Nature medicine
Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment.
JCI insight
Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.
bioRxiv : the preprint server for biology
Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma.
Journal for immunotherapy of cancer
A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis.
bioRxiv : the preprint server for biology
Epigenetic reprogramming shapes the cellular landscape of schwannoma.
Nature communications
Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.
bioRxiv : the preprint server for biology
Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment.
bioRxiv : the preprint server for biology
Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.
bioRxiv : the preprint server for biology
Simvastatin induces human gut bacterial cell surface genes.
Molecular microbiology
The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation.
bioRxiv : the preprint server for biology
Computational Methods for Single-Cell Proteomics.
Annual review of biomedical data science
Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Science (New York, N.Y.)
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity
A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection.
Cell reports
Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Variation of Immune Cell Responses in Humans Reveals Sex-Specific Coordinated Signaling Across Cell Types.
Frontiers in immunology
Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology
A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates.
Frontiers in immunology
Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.
Proceedings of the National Academy of Sciences of the United States of America
Archetypes of checkpoint-responsive immunity.
Trends in immunology
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes.
JCI insight
Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer.
Journal for immunotherapy of cancer
Systemic immunity in cancer.
Nature reviews. Cancer
Landscape of coordinated immune responses to H1N1 challenge in humans.
The Journal of clinical investigation
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity.
Nature immunology
ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network.
BMC bioinformatics
Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.
Annals of surgical oncology
Systemic dysfunction and plasticity of the immune macroenvironment in cancer models.
Nature medicine
Depletion of microbiome-derived molecules in the host using Clostridium genetics.
Science (New York, N.Y.)
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nature immunology
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
Nature biotechnology
Hacking the 'Cellular Immunology Agency': T cells caught in the act.
Nature immunology
Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis.
Methods in molecular biology (Clifton, N.J.)
Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment.
Cancer immunology research
Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Cell stem cell
Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.
Cell stem cell
Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells.
Cell reports
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
Nature medicine
Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy.
Journal of immunology (Baltimore, Md. : 1950)
Automated mapping of phenotype space with single-cell data.
Nature methods
Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure.
Toxicology letters
IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system.
Science (New York, N.Y.)
Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm.
Nature protocols
Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America
Systems biology. Conditional density-based analysis of T cell signaling in single-cell data.
Science (New York, N.Y.)
A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
The transcriptional landscape of αβ T cell differentiation.
Nature immunology
Risks and benefits of testosterone therapy in older men.
Nature reviews. Endocrinology
Thyrotoxicosis with post-treatment hypothyroidism in a patient with acute suppurative thyroiditis due to porphyromonas.
Thyroid : official journal of the American Thyroid Association